Risk of weight gain for specific antipsychotic drugs: a meta-analysis
نویسندگان
چکیده
منابع مشابه
Metformin in prevention and treatment of antipsychotic induced weight gain: a systematic review and meta-analysis
BACKGROUND Most antipsychotics are associated with weight gain and other metabolic complications. Several randomized trials have shown metformin to be effective, but this still hasn't been included in clinical guidelines on managing antipsychotic induced weight gain. METHODS All double blind placebo controlled trials assessing the efficacy of metformin in the treatment of antipsychotic induce...
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BACKGROUND The leptin -2548G/A (rs7799039) gene polymorphism has been implicated in susceptibility to antipsychotic-induced weight gain (AIWG), but study results are still controversial. The present meta-analysis was performed to investigate the relationship between the leptin -2548G/A gene polymorphism and AIWG. METHODS Electronic databases were searched for eligible articles in English and ...
متن کاملWeight gain in antipsychotic-naive patients: a review and meta-analysis.
BACKGROUND Weight gain is a long-recognized side-effect of antipsychotic (AP) drugs and a major health concern in the treatment of psychosis. The strength of the causal relationship between AP drug exposure and weight gain can only be gauged by a drugs trial conducted on AP-naive patients. METHOD We conducted a review of the literature regarding the amount of weight gain induced by APs in AP-...
متن کاملA possible gut microbiota basis for weight gain side effects of antipsychotic drugs
Weight gain is a well-established side effect of both conventional and newer anti-psychotic drugs, but the cause is not well understood. Recent studies correlate obesity with the presence or absence of particular genetic sequences in the gut microbiota. We identified strong associations between protein targets of antipsychotics and microbiota sequences directly related to weight regulation in h...
متن کاملCombination of Metformin and Lifestyle Intervention for Antipsychotic-Related Weight Gain: A Meta-Analysis of Randomized Controlled Trials.
INTRODUCTION Weight gain is a common antipsychotic (AP)-related adverse drug reaction (ADR) that can increase the risk of cardiovascular diseases and premature mortality. This meta-analysis examined the efficacy and tolerability of combining metformin and lifestyle intervention for AP-related weight gain in schizophrenia. METHODS Randomized controlled trials (RCTs) with meta-analyzable data w...
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ژورنال
عنوان ژورنال: npj Schizophrenia
سال: 2018
ISSN: 2334-265X
DOI: 10.1038/s41537-018-0053-9